Salt Point House / Thomas Phifer and Partners

first_imgShareFacebookTwitterPinterestWhatsappMailOrhttps://www.archdaily.com/81621/salt-point-house-thomas-phifer Clipboard ArchDaily CopyHouses•Salt Point, United States Salt Point House / Thomas Phifer and PartnersSave this projectSaveSalt Point House / Thomas Phifer and Partners Area:  204 m² Year Completion year of this architecture project Architects: Thomas Phifer and Partners Area Area of this architecture project Photographs:  Scott FrancesText description provided by the architects. In brilliant daylight, the Salt Point House has an ethereal presence as elusive and weightless as a mirage, its edges seemingly dissolving into the surrounding forested landscape. Yet with changing light, the house transforms itself, shifting by turns from gossamer and nearly transparent to opaque and quietly monumental. Perhaps even more remarkable: the architecture achieves these poetic qualities with a modest palette of ordinary materials and simple volumes.Save this picture!© Scott FrancesRecommended ProductsWindowsAir-LuxSliding Window – CurvedLouvers / ShuttersLunawoodThermowood BattensEnclosures / Double Skin FacadesIsland Exterior FabricatorsCurtain Wall Facade SystemsWindowsSolarluxSliding Window – CeroIn the most basic terms, the house is an open-ended, painted-cedar box, lined in maple plywood and overlaid on two sides with corrugated screens of perforated, stainless steel. Its brief could hardly have been more humble. The clients, a New York City couple, wistful for the key elements of their former weekend getaway—the rustic hunting shack they had once hoped to buy—wanted a small, comfortable, easily maintained, two-bedroom retreat with an open living area and a screened-in porch. Certainly, no exotic requirements, but in the sheer modesty and economic restraint of this commission, the architects found opportunity to distill form, proportion, materiality, and detail to their essence. Inspiration also came, abundantly, from the site—an idyllic clearing on a wooded, nine-acre parcel in New York’s Hudson Valley, along a pond that spills into a small waterfall. Save this picture!© Scott FrancesOutside, the rippled screens, veils of stainless steel, simultaneously hide and reveal, filtering readings out to the landscape and in to the structure’s pure volumes, its solids, shadows, and flickering voids. At once deep and lightly layered, both transparent and opaque, the perforated metal cloak registers muted reflections of the surroundings in seasonal flux. Even the screened-in porch is detailed with minimalist precision, as if simply delineating a great, cubic volume of air. This is an architecture that accepts yet transcends the sheer simplicity of the plywood box, expressing and dematerializing the skin as it quietly renders the prosaic sublime.Save this picture!© Scott FrancesProject gallerySee allShow lessBC Hyrdo Energy ExperimentArticlesSilver Shack / Chae Pereira ArchitectsArticles Share CopyAbout this officeThomas Phifer and PartnersOfficeFollowProductsGlassSteel#TagsProjectsBuilt ProjectsSelected ProjectsResidential ArchitectureHousesDabasSalt PointWoodHouses3D ModelingUnited StatesPublished on October 14, 2010Cite: “Salt Point House / Thomas Phifer and Partners” 14 Oct 2010. ArchDaily. Accessed 12 Jun 2021. ISSN 0719-8884Read commentsBrowse the CatalogPanels / Prefabricated AssembliesTechnowoodGRP Siding Façade SystemGlassMitrexSolar PanelsMetal PanelsAurubisCopper Alloy: Nordic BrassWoodParklex International S.L.Wood cladding – FacadeSignage / Display SystemsGoppionDisplay Case – Qd-ClassSkylightsLAMILUXGlass Skylight FE PassivhausStonesCosentinoDekton Surfaces – Cap Ferrat BuildingStonesNeolithSintered Stone – Strata Argentum – Classtone CollectionAcousticSchöckStaircase Insulation – Tronsole®CeramicsTerrealCustom Shape Terracotta CladdingSeatingInterstuhlPillows – HUBPartitionsBuzzispacePrivacy Booth – BuzziRingMore products »Read commentsSave想阅读文章的中文版本吗?盐点住宅 / Thomas Phifer是否翻译成中文现有为你所在地区特制的网站?想浏览ArchDaily中国吗?Take me there »✖You’ve started following your first account!Did you know?You’ll now receive updates based on what you follow! Personalize your stream and start following your favorite authors, offices and users.Go to my stream United States Projects “COPY” Year:  Save this picture!© Scott Frances+ 11 Share 2007 “COPY” Houses ShareFacebookTwitterPinterestWhatsappMailOrhttps://www.archdaily.com/81621/salt-point-house-thomas-phifer Clipboard Salt Point House / Thomas Phifer and Partners Photographslast_img read more

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Nakahouse / XTEN Architecture

first_img Products translation missing: en-US.post.svg.material_description Photographs:  Steve King Manufacturers Brands with products used in this architecture project CopyHouses, Renovation•Los Angeles, United States General Contractor: Houses Products used in this ProjectFaucetsDornbrachtKitchen Fittings – ElioArchitect:XTEN ArchitectureProject Team:Monika Haefelfinger, Austin Kelly, Scott Utterstrom, Jae Rodriguez, Qichen Cao, Karin Nelson, Joseph Tran, Karin Von WylCity:Los AngelesCountry:United StatesMore SpecsLess SpecsText description provided by the architects. Nakahouse is an abstract remodel of a 1960’s hillside home located on a West facing ridge in the Hollywood Hills, just below the Hollywood sign. To the South and West are views of the Beechwood Canyon; to the East is a protected natural ravine, with a view of Griffith Park Observatory in the distance. Save this picture!The existing home was built as a series of interconnected terraced spaces on the downslope property. Due to geotechnical, zoning and budget constraints the foundations and building footprint were maintained in the current design. The interior was completely reconfigured however, and the exterior was opened up to the hillside views and the natural beauty of the surroundings. A large terrace was added to link the kitchen/ dining area with the living room, with a steel stair leading to a rooftop sundeck. Terraces were also added to the bedroom wing and the upper master bedroom suite to extend the interior spaces through floor to ceiling glass sliding panels that disappear into adjacent walls when open. Save this picture!diagramThe exterior walls are finished in a smooth black Meoded ventetian plaster system, designed to render the building as a singular sculptural object set within the lush natural setting. A series of abstract indoor-outdoor spaces with framed views to nature are rendered in white surfaces of various materials and finishes; lacquered cabinetry, epoxy resin floors and decks and painted metal. Save this picture!© Steve KingThe contrast between the interior and exterior of the house is intentional and total. While the exterior is perceived as a specific finite and irregular object in the landscape the opposite occurs inside the building. Once inside the multitude of white surfaces blend the rooms together, extending ones sense of space and creating a heightened, abstract atmosphere from which to experience the varied forms of the hillside landscape.Save this picture!Project gallerySee allShow lessKirkkojärvi Comprehensive School / Verstas ArchitectsArticlesUrban Farm Design CompetitionArticles Share Save this picture!© Steve King+ 16 Share Architects: XTEN Architecture Area Area of this architecture project Geotech: ArchDaily Nakahouse / XTEN ArchitectureSave this projectSaveNakahouse / XTEN Architecture Area:  2700 ft² Year Completion year of this architecture project Structural Engineer: 2011 Photographscenter_img CY Geotech “COPY” Nakahouse / XTEN Architecture ShareFacebookTwitterPinterestWhatsappMailOrhttps://www.archdaily.com/166226/nakahouse-xten-architecture Clipboard Projects United States Year:  Manufacturers: Dornbracht, Hansgrohe, Benjamin Moore, Caesarstone, Carl Hansen, Dex o Tex, FRANKE, Gessi, Miele, Milgard, Neo-Metro, SOSS, Thermador, Environment, Escenium HAUS, Halo, Meoded Paint, Titus, Type V-N, Western Integrated, +1Wetstyle-1 “COPY” Axial Engineering Group ShareFacebookTwitterPinterestWhatsappMailOrhttps://www.archdaily.com/166226/nakahouse-xten-architecture Clipboard NWGC INC. CopyAbout this officeXTEN ArchitectureOfficeFollow#TagsProjectsBuilt ProjectsSelected ProjectsResidential ArchitectureHousesRefurbishmentRenovationLos AngelesDabasHouses3D ModellingUnited StatesPublished on September 07, 2011Cite: “Nakahouse / XTEN Architecture” 07 Sep 2011. ArchDaily. Accessed 12 Jun 2021. ISSN 0719-8884Read commentsBrowse the CatalogAluminium CompositesTechnowoodWood Siding in KSR Villa BodrumWindowsMitrexSolar WindowMetal PanelsAurubisCopper Alloy: Nordic RoyalVentilated / Double Skin FacadeSTAC BONDAssembly Systems – GluedLightsLouis PoulsenLamps – LP Slim BoxUrban ApplicationsIsland Exterior FabricatorsPublic Safety Answering Center II Envelope SystemPodsTrimoModular Space SolutionsHanging LampsAxolightPendant Lights – HoopsStonesFranken-SchotterFlooring and Wall Tiles – Dietfurt LimestoneVentilated / Double Skin FacadeULMA Architectural SolutionsPaper Facade Panel in Nokia LibraryCabinetsburgbadWall Cabinet – Sys30AcousticUnika VaevAcoustics – Ecoustic® Foliar TileMore products »Read commentsSave想阅读文章的中文版本吗?纳卡住宅 / XTEN Architecture是否翻译成中文现有为你所在地区特制的网站?想浏览ArchDaily中国吗?Take me there »✖You’ve started following your first account!Did you know?You’ll now receive updates based on what you follow! Personalize your stream and start following your favorite authors, offices and users.Go to my streamlast_img read more

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300 Ivy Street / David Baker Architects

first_imgArchDaily Architects: David Baker Architects Year Completion year of this architecture project Restaurants & Bars Lighting Designer: Landscape: 2014 Murphy Burr Curry ShareFacebookTwitterPinterestWhatsappMailOrhttps://www.archdaily.com/592797/300-ivy-street-david-baker-architects Clipboard CopyAbout this officeDavid Baker ArchitectsOfficeFollowProductsWoodSteelConcrete#TagsProjectsBuilt ProjectsSelected ProjectsHospitality ArchitectureRestaurants & BarsResidential ArchitectureHousingCommercial ArchitectureRetailStoreSan FranciscoRetailHousingHotels and RestaurantsResidentialUnited StatesPublished on January 31, 2015Cite: “300 Ivy Street / David Baker Architects” 31 Jan 2015. ArchDaily. Accessed 11 Jun 2021. ISSN 0719-8884Read commentsBrowse the CatalogVentilated / Double Skin FacadeTechnowoodProfile Façade SystemGlassMitrexSolar PanelsMetal PanelsAurubisCopper Alloy: Nordic RoyalFiber Cements / CementsEQUITONEFiber Cement Facade Panel PicturaCultural / PatrimonialIsland Exterior FabricatorsSeptember 11th Memorial Museum Envelope SystemConcreteKrytonSmart ConcreteSignage / Display SystemsGoppionDisplay Case – B-ClassMetal PanelsLorin IndustriesAnodized Aluminum – Stainless Steel FinishesWoodStructureCraftEngineering – Mass TimberWindowspanoramah!®ah!38 – FlexibilityChairsSellexChair – IrinaBathroom FurnitureKaleBathroom Cabinets – ZeroMore products »Read commentsSave想阅读文章的中文版本吗?常春藤街300号/ David Baker Architects是否翻译成中文现有为你所在地区特制的网站?想浏览ArchDaily中国吗?Take me there »✖You’ve started following your first account!Did you know?You’ll now receive updates based on what you follow! Personalize your stream and start following your favorite authors, offices and users.Go to my stream Year:  Save this picture!© Bruce Damonte+ 26 Share United States Year:  Developer:Ivy Grove PartnersDesign/Fabrication:Pacassa StudiosOutdoor Furnishings:OHIO DesignCity:San FranciscoCountry:United StatesMore SpecsLess SpecsSave this picture!© Bruce DamonteText description provided by the architects. This mixed-use development of urban market-rate homes, restaurants and shops continues the repair of the neighborhood fabric damaged by the removal of the Central Freeway. The design was developed as a balance of inside and out: equally addressing the needs of residents for high- quality, modern, peaceful homes with the needs of the community for vibrant retail, a place for pedestrians, and a texture and scale that respects the surrounding buildings.Save this picture!© Bruce DamonteThe beginning basis of the design was a consideration of how the building would touch the public space, and the strategy used throughout is the ju- dicious “drawing back” of the building from the property line, effectively re- turning space to the public realm to create the comfortable, human-scaled edges. This building maximizes the site edge with lively uses, widened sidewalks, and a gracious entry sequence, encouraging retail spaces and residential stoops to connect outward to the street.Save this picture!© Bruce DamonteAn emphasis on the corner bays creates a gateway feeling as the busy one-way traffic approaches the heart of Hayes Valley. At a smaller scale, transom windows line the retail arcade, referencing the common typology of the neighborhood and bringing daylight into the shops.Save this picture!First Floor PlanThe main entrance is around the corner from the building’s most public face, on the smaller and quieter Ivy Street. The approach to this entrance has been arranged as a “decompression” sequence that guides residents from the bustle of Gough Street towards the sanctuary of the building.Save this picture!© Bruce DamonteInside, units are designed with modern simplicity, maximizing views with floor-to-ceiling windows and continuing the connection to outside. Just as the ground floor of the building has been pulled in away from the edge to create additional public space, the units above extend, pushing private space out over the busy sidewalks.Save this picture!© Bruce DamonteThe neighborhood-inspired pattern of bays creates unique edges for the units, adding interest. The rooftop has an outdoor entertaining kitchen, a lavish protea garden, and a patio for lounging. A perimeter of bamboo defines the common space, which is lined with planters available to residents for gardening.Save this picture!© Bruce DamonteOn the smaller scaled Ivy Street, as height limits drop, the building chang- es tone and becomes a row of three-story townhouses. By moving the trees into planters between the street parking, pulling the building a few feet back from the property line, and lifting the first living floor off street level via indoor stoops, the design widened the sidewalk for pedestrians and buffered the townhouses from the fully public realm.Save this picture!© Bruce DamonteProject gallerySee allShow lessWOTHOUSE / NSW ASSelected ProjectsAD Round Up: Classics in BrickArchitecture NewsProject locationAddress:300 Ivy Street, San Francisco, CA 94102, United StatesLocation to be used only as a reference. It could indicate city/country but not exact address. Share Structural Engineer: photographs:  Bruce DamontePhotographs:  Bruce Damonte “COPY” Robison Engineering Contractor: 300 Ivy Street / David Baker ArchitectsSave this projectSave300 Ivy Street / David Baker Architects MEP: Cahill Construction Sandis Horton Lees Brogden Lighting Design Projects Civil Engineer: Fletcher Studio 300 Ivy Street / David Baker Architects CopyRestaurants & Bars, Housing, Store•San Francisco, United States Photographs ShareFacebookTwitterPinterestWhatsappMailOrhttps://www.archdaily.com/592797/300-ivy-street-david-baker-architects Clipboard 2014 “COPY”last_img read more

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uberGIVING hits UK cities in support of Cancer Research UK

first_img About Melanie May Melanie May is a journalist and copywriter specialising in writing both for and about the charity and marketing services sectors since 2001. She can be reached via www.thepurplepim.com. AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to LinkedInLinkedInShare to EmailEmailShare to WhatsAppWhatsAppShare to MessengerMessengerShare to MoreAddThis23 Tagged with: corporate Donated goods donated services According to Uber, some of the items collected included a guitar, a Nintendo 64, circus stilts, a replica jet, three TVs, and a commercial insect catcher, with demand leading the company to extend the exercise in London for a second day on Sunday 3 June.This is not the first time Uber has picked up charity donations for free. In 2015, it supported Save the Children’s Child Refugee Crisis Appeal with an UberGIVING campaign that saw it partner with charities in 20 European countries in response to the refugee crisis. Following this, for Christmas 2016 uberGIVING took place in 83 cities across Europe, the Middle East, and Africa, partnering with a different local charity in each country, including Age UK. Melanie May | 4 June 2018 | News  229 total views,  1 views today This weekend saw Uber hit the streets in ten cities UK-wide to pick up donations for Cancer Research UK, as well as its usual customers.uberGIVING took place on 2 June in London (Zones 1 and 2), Manchester, Birmingham, Leeds, Merseyside, Bristol, Brighton, Cardiff, Glasgow, and Edinburgh. Uber asked people to bag up any items they wanted to donate to Cancer Research UK, and then on Saturday 2 June, to open up the Uber app, tap the uberGIVING in-app card and request a free pick-up to a Cancer Research UK shop.  230 total views,  2 views today AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to LinkedInLinkedInShare to EmailEmailShare to WhatsAppWhatsAppShare to MessengerMessengerShare to MoreAddThis23 uberGIVING hits UK cities in support of Cancer Research UKlast_img read more

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International Statement of Ethical Principles approved at Summit

first_img Melanie May | 6 July 2018 | News International Statement of Ethical Principles approved at Summit A revised version of the International Statement of Ethical Principles has been approved at this year’s International Fundraising Summit, held on 5 July.National fundraising associations from across the globe attended the Summit hosted by the Institute of Fundraising, representing countries including the US, Canada, Italy, Brazil, France, Belgium, and Sweden, as well as the UK.Delegates gathered to reflect and discuss common opportunities, challenges and solutions for developing fundraising as well as to share insight and to approve a revised version of the International Statement of Ethical Principles.The Statement outlines an ethical approach for fundraisers, wherever they work, and centres on shared principles for fundraising, which are rooted in honesty, respect, integrity, transparency and responsibility. It says it “does not replicate, replace, or supersede any laws or codes of conduct that are in place in any individual country, as it is expected that fundraisers will fully observe the law wherever they work,” but “outlines the ethical approach and articulates the values that drive fundraising professionals and provides a framework of how we will work globally.”Peter Lewis, Chief Executive of the Institute of Fundraising said:“I’m delighted to welcome the international fundraising community to London to sign the International Statement of Ethical Principles. It’s an important symbol of international cooperation across the fundraising community and recognises that wherever supporters are asked for money, it should always happen to a high standard and according to ethical principles. I’m proud that the IoF is supporting this work, which contributes to the delivery of excellent standards of fundraising across the world.”  55 total views,  1 views today Advertisement About Melanie May Melanie May is a journalist and copywriter specialising in writing both for and about the charity and marketing services sectors since 2001. She can be reached via www.thepurplepim.com.center_img AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to LinkedInLinkedInShare to EmailEmailShare to WhatsAppWhatsAppShare to MessengerMessengerShare to MoreAddThis1  56 total views,  2 views today AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to LinkedInLinkedInShare to EmailEmailShare to WhatsAppWhatsAppShare to MessengerMessengerShare to MoreAddThis1last_img read more

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India: Tamil Nadu TV reporter killed because of status as journalist

first_imgNews Reporters Without Borders (RSF) reiterates the urgent need for legislation protecting media personnel in India after a reporter for a Tamil-language TV channel in Chennai, the capital of the southeastern state of Tamil Nadu, was murdered on 8 November as a direct result of his status as a journalist. A week before his death, Moses did a report for Tamizhan TV in which he investigated local cannabis dealing. This might have been the motive for his murder but his father, Gnanaraj Jesudasan, who is himself a print media reporter, is not convinced. Moses is at least the second Indian journalist to be killed in connection with their work in 2020. Newspaper reporter Shubham Mani Tripathi died after being shot six times, three of them in the head, in a suburb of Lucknow, the capital of the northern state of Uttar Pradesh, on 19 June. Shortly before his death, he said he feared he could be killed because of his investigations into land expropriations linked to illegal sand mining. IndiaAsia – Pacific Protecting journalists Organized crimeViolence RSF_en November 12, 2020 India: Tamil Nadu TV reporter killed because of status as journalist Receive email alerts to go further India is ranked 142nd out of 180 countries in RSF’s 2020 World Press Freedom Index. Punitive raid News News “Although he had nothing to do with it, local residents named my son as the instigator on the assumption that his status as a journalist would allow him to be spared,” Jesudasan said. “We urge the Tamil Nadu prosecutor’s office to ensure that the perpetrators and instigators of Isravel Moses’s murder are properly brought before a court,” said Daniel Bastard, the head of RSF’s Asia-Pacific desk. “It is unacceptable for a journalist to be murdered when the police knew there were threats to his safety. We urge the Tamil Nadu government to submit a bill on journalists’ safety as soon as possible so that this kind of mishap does not recur.” IndiaAsia – Pacific Protecting journalists Organized crimeViolence Organisation center_img “His murder is not directly linked to any investigation or report that he broadcast,” Jesudasan told RSF by telephone. Jesudasan thinks it was due to the fact that Moses and his family lived near a plot of land that was seized by a local gang. Follow the news on India RSF demands release of detained Indian journalist Siddique Kappan, hospitalised with Covid-19 Second journalist killed in 2020 India: RSF denounces “systemic repression” of Manipur’s media Help by sharing this information April 27, 2021 Find out more News Tamizhan TV reporter Isravel Moses was hacked to death with machetes in the Chennai suburb of Kundrathur on the evening of 8 November after his neighbours identified him as a journalist to members of the local underworld. The gang delivered stones to the site with which to later start building, but the stones were removed by local residents, resulting in a raid by the gang with a view to identifying and punishing those responsible. March 3, 2021 Find out more But instead, it was because of his status as a journalist that Moses was killed. He had previously notified the police that he was under threat. Four individuals have been arrested since his murder. Isravel Moses had previously notified the police that he was under threat (photo: Twitter). Indian journalist wrongly accused of “wantonly” inaccurate reporting February 23, 2021 Find out morelast_img read more

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Warning against bogus traders

first_imgAdvertisement Previous articleFisherman’s plea for Plassey riverNext articleEditorial – Local politician admin Print THE Garda Siochana are alerting the public to bogus traders, “running rampant in Limerick.”They are warning against allowing strangers into their homes.Sign up for the weekly Limerick Post newsletter Sign Up Two men have reportedly been calling to houses of the elderly in the Newcastlewest area and posing as plain clothes Gardai. The con men have been telling residents that they are there to check their alarms and are asking if money is kept in the house.The men in question claimed that they were detectives from Cork.Gardai would like to emphasise that they do not send plain clothes Gardai to the homes of the elderly to check alarms or ask if money is kept in the home.In another case of bogus trading, a man called to the home of an elderly lady in the Mayorstone area and told her he was there to clean gutter pipes on her house. The lady suffers from dementia and was somewhat confused as to whether she gave the con man the money or if he stole it, but either way she found herself relieved of 250 euro.The culprit in this case is described as having a black moustache, but no other description was availableGardai feel that this type of crime will become more common considering the current difficult economic situation. They again appeal to people to be extremely careful about leaving strangers into your home and not to allow anyone to do any work on your property without first checking them out with a neighbour, friend or relative.Gardai advise taking extra care to make sure front and rear doors are closed so that nobody can walk in without you opening the door and to attach a door chain to the front door if one is not already in place.If anyone comes across these bogus traders Gardai ask that you contact them straight away before they con another innocent person. Linkedin Twittercenter_img Facebook Email WhatsApp NewsLocal NewsWarning against bogus tradersBy admin – April 30, 2009 502 last_img read more

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Selecta Biosciences and AskBio Initiate First-in-Human Dose-Escalation Study to Evaluate ImmTOR™ in Gene Therapy

first_img Facebook Twitter By Digital AIM Web Support – February 17, 2021 Local NewsBusiness Twitter Previous articleQuotient Announces Agreement to Power In-Lane Digital Promotions for Major Drug RetailerNext articlePG&E Appoints Industry Expert Joseph Forline to Lead Gas Operations Digital AIM Web Support Pinterest WhatsAppcenter_img WATERTOWN, Mass., and Research Triangle Park, N.C., Feb. 17, 2021 /PRNewswire/ — Selecta Biosciences, Inc. (NASDAQ: SELB) and Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG, today announced the initiation of a Phase 1 dose-escalation trial of SEL-399, an adeno-associated viral serotype 8 (AAV8) empty vector capsid (EMC-101) containing no DNA combined with ImmTOR™. The trial aims to determine the optimal dose of ImmTOR to mitigate the formation of antibodies to AAV8 capsids used in gene therapies. “We are pleased to further evaluate ImmTOR’s ability to reduce the formation of antibodies to AAV capsids and potentially enable gene therapy redosing by having initiated this dose-escalation study of SEL-399,” said Carsten Brunn, Ph.D., president and chief executive officer of Selecta. “This trial builds upon our strong preclinical data in non-human primates and marks the first time that ImmTOR in conjunction with an AAV capsid has been dosed in humans, which is a significant milestone. Data from this study will inform the design of future clinical trials in patients as we seek to unlock the full potential of gene therapy.” The dose-escalation trial of SEL-399 is designed to evaluate the safety and preliminary efficacy of ImmTOR in gene therapy. The study, being conducted in healthy volunteers at the SGS Life Sciences Clinical Pharmacology Unit in Antwerp, Belgium, plans to enroll up to 45 subjects to investigate increasing doses of ImmTOR and EMC-101. Subjects will be randomized in a 3:1 ratio of ImmTOR plus empty AAV8 capsid to empty capsid alone. Preliminary efficacy will be measured by assessing levels of AAV8-specific neutralizing antibodies. Jude Samulski, Ph.D., chief scientific officer and co-founder of AskBio said, “By determining the dose at which ImmTOR is able to inhibit the formation of AAV-specific antibodies, this study could be a significant first step toward overcoming some of the unwanted immune responses associated with gene therapies. We look forward to using these findings to inform future studies as we work to develop strategies for repetitive dosing of AAV, thus extending durability of expression.” Selecta and AskBio expect to report initial results from this clinical trial in the fourth quarter of 2021. About Selecta Biosciences, Inc. Selecta Biosciences Inc. (NASDAQ: SELB) is leveraging its clinically validated ImmTOR™ platform to develop tolerogenic therapies that selectively mitigate unwanted immune responses. With a proven ability to induce tolerance to highly immunogenic proteins, ImmTOR has the potential to amplify the efficacy of biologic therapies, including redosing of life-saving gene therapies, as well as restore the body’s natural self-tolerance in autoimmune diseases. The company’s first program aimed at addressing immunogenicity to AAV gene therapies is expected to enter clinical trials in early 2021 in partnership with AskBio for the treatment of methylmalonic acidemia (MMA), a rare metabolic disorder. A wholly-owned program focused on addressing IgA nephropathy driven by ImmTOR and a therapeutic enzyme is also in development among additional product candidates. Selecta recently licensed its Phase 3 clinical product candidate, SEL-212, in chronic refractory gout to Sobi. For more information, please visit www.selectabio.com. About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 500 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com or follow us on LinkedIn. About Bayer Bayer is a global enterprise with core competencies in the life science fields of health care and nutrition. Its products and services are designed to benefit people by supporting efforts to overcome the major challenges presented by a growing and aging global population. At the same time, the Group aims to increase its earning power and create value through innovation and growth. Bayer is committed to the principles of sustainable development, and the Bayer brand stands for trust, reliability and quality throughout the world. In fiscal 2019, the Group employed around 104,000 people and had sales of 43.5 billion euros. Capital expenditures amounted to 2.9 billion euros, R&D expenses to 5.3 billion euros. For more information, visit www.bayer.com. AskBio Forward-Looking Statements This press release contains “forward-looking statements.” Any statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. Words such as “believes,” “anticipates,” “plans,” “expects,” “will,” “intends,” “potential,” “possible” and similar expressions are intended to identify forward-looking statements. These forward-looking statements include without limitation statements regarding AskBio’s pipeline of development candidates; AskBio’s collaboration with Selecta; AskBio’s clinical trials, including its ability to enroll subjects, the timing of any such trials and any potential side effects; whether ImmTOR will be able to reduce the formation of antibodies to AAV capsids and potentially enable gene therapy redosing; the timing of and results from the SEL-399/101 trial; whether the SEL-399/101 study could be a significant first step in overcoming the immunogenicity concerns associated with gene therapies; AskBio’s strategies for repetitive dosing of AAV, extending durability of expression; AskBio’s goal of developing life-saving medicines aimed at curing genetic diseases; and the potential benefits of AskBio’s development candidates to patients. These forward-looking statements involve risks and uncertainties, many of which are beyond AskBio’s control. Known risks include, among others: AskBio may not be able to execute on its business plans and goals, including meeting its expected or planned regulatory milestones and timelines, clinical development plans and bringing its product candidates to market, due to a variety of reasons, including the ongoing COVID-19 pandemic, possible limitations of company financial and other resources, manufacturing limitations that may not be anticipated or resolved in a timely manner, potential disagreements or other issues with our third-party collaborators and partners, and regulatory, court or agency feedback or decisions, such as feedback and decisions from the United States Food and Drug Administration or the United States Patent and Trademark Office. Any of the foregoing risks could materially and adversely affect AskBio’s business and results of operations. You should not place undue reliance on the forward-looking statements contained in this press release. AskBio does not undertake any obligation to publicly update its forward-looking statements based on events or circumstances after the date hereof. Selecta Forward-Looking Statements Any statements in this press release about the future expectations, plans and prospects of Selecta Biosciences, Inc. (“the company”), including without limitation, statements regarding the unique proprietary technology platform of the company, and the unique proprietary platform of its partners, the potential of ImmTOR to enable re-dosing of AAV gene therapy, the potential treatment applications of product candidates utilizing the ImmTOR platform in areas such as gene therapy, the ability of the Company and AskBio to develop gene therapy products using ImmTOR and AskBio’s technology, the novelty of treatment paradigms that the Company is able to develop, whether the observations made in non-human primate study subjects will translate to studies performed with human beings, the potential of any therapies developed by the company and AskBio to fulfill unmet medical needs, the company’s plan to apply its ImmTOR technology platform to a range of biologics for rare and orphan genetic diseases, the potential of the company’s intellectual property to enable repeat administration in gene therapy product candidates and products, the ability to re-dose patients and the potential of ImmTOR to allow for re-dosing, the potential to safely re-dose AAV, the ability to restore transgene expression, the potential of the ImmTOR technology platform generally and the company’s ability to grow its strategic partnerships, and other statements containing the words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “hypothesize,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “would,” and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including, but not limited to, the following: the uncertainties inherent in the initiation, completion and cost of clinical trials including proof of concept trials, including the uncertain outcomes, the availability and timing of data from ongoing and future clinical trials and the results of such trials, whether preliminary results from a particular clinical trial will be predictive of the final results of that trial or whether results of early clinical trials will be indicative of the results of later clinical trials, the ability to predict results of studies performed on human beings based on results of studies performed on non-human primates, the unproven approach of the company’s ImmTOR technology, potential delays in enrollment of patients, undesirable side effects of the company’s product candidates, its reliance on third parties to manufacture its product candidates and to conduct its clinical trials, the company’s inability to maintain its existing or future collaborations, licenses or contractual relationships, its inability to protect its proprietary technology and intellectual property, potential delays in regulatory approvals, the availability of funding sufficient for its foreseeable and unforeseeable operating expenses and capital expenditure requirements, the company’s recurring losses from operations and negative cash flows from operations raise substantial doubt regarding its ability to continue as a going concern, substantial fluctuation in the price of its common stock, and other important factors discussed in the “Risk Factors” section of the company’s most recent Quarterly Report on Form 10-Q, and in other filings that the company makes with the Securities and Exchange Commission. In addition, any forward-looking statements included in this press release represent the company’s views only as of the date of its publication and should not be relied upon as representing its views as of any subsequent date. The company specifically disclaims any intention to update any forward-looking statements included in this press release. View original content to download multimedia: http://www.prnewswire.com/news-releases/selecta-biosciences-and-askbio-initiate-first-in-human-dose-escalation-study-to-evaluate-immtor-in-gene-therapy-301229448.html SOURCE Asklepios BioPharmaceutical, Inc. Facebook TAGS  Pinterest Selecta Biosciences and AskBio Initiate First-in-Human Dose-Escalation Study to Evaluate ImmTOR™ in Gene Therapy WhatsApplast_img read more

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Man in Derry charged with a number of drugs-related offences

first_img WhatsApp Man in Derry charged with a number of drugs-related offences Facebook Google+ Homepage BannerNews Google+ WhatsApp Twitter RELATED ARTICLESMORE FROM AUTHOR Facebook Pinterest Important message for people attending LUH’s INR clinic center_img Twitter Police in Derry have charged a 34-year-old man with a number of drugs-related offences, including possession of a Class A controlled drug and possession of a Class B controlled drug.Police say he is due to appear before Derry Magistrates’ Court today, Saturday 13 March.As is normal procedure, all charges will be reviewed by the Public Prosecution Service.This follows the search of a house in Derry on Thursday. Loganair’s new Derry – Liverpool air service takes off from CODA News, Sport and Obituaries on Monday May 24th Previous articleCSO figures show 143 people in Donegal have died with Covid-19Next articleSuccessful Friday for Donegal Jockeys News Highland By News Highland – March 13, 2021 DL Debate – 24/05/21 Arranmore progress and potential flagged as population grows Pinterest Nine til Noon Show – Listen back to Monday’s Programmelast_img read more

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Hazardous weather expected as 2 storms travel across US for New Year’s Eve

first_imgABC NewsBy DANIEL MANZO, ABC News(NEW YORK) — A major storm brought heavy snow, heavy rain and gusty winds to parts of the Southwest on Monday, especially in Southern California.This is the beginning of a multi-storm event that will unfold over the remainder of the holiday week, with messy consequences still to come for much of the country.Up to a foot of snow was reported in the mountains outside of Los Angeles, and very heavy snow caused major traffic delays near Mount Baldy.Over 3 inches of rain fell in Santa Barbara, California, and downtown Los Angeles saw 1.81 inches of rain. This was the first significant rainfall of the season for the region.On Tuesday morning, the storm will move through the Central Plains. It has already closed parts of I-80 in Nebraska due to hazardous road conditions.Winter weather alerts have been issued for at least 40 million Americans, from Utah to Michigan, as this storm moves eastward.Of particular concern Tuesday morning is the combination of snow, freezing rain and sleet moving through parts of Kansas and northwest Missouri. This could create dangerous travel conditions on roadways and cause power outages.Heavy snow will expand into parts of the upper Midwest, especially from Minnesota to eastern Iowa and western Illinois. Up to 10 inches of snow may fall along the Illinois and Iowa border. This could cause major travel delays in the region.Then, as the core of the storm passes into southern Canada, the trailing cold front on Thursday morning should bring a large line of rain transitioning to snow from the northeast back through the Southern Plains. Additionally, some snow may fall in the interior Northeast as well on Thursday morning. All of this could cause travel delays as Americans head toward New Year’s Eve.Immediately behind this system on New Year’s Eve and New Year’s Day, another storm will start organizing in the South, pushing heavy rain and storms toward the Gulf Coast.As this system becomes more organized, strong winds and brief tornadoes could move across parts of the Gulf Coast in time for New Year’s Eve and New Year’s Day.The storm will push a rather wide swath of snow and wintry mix from Texas to Indiana, causing power outages and dangerous travel conditions due to ice.Eventually, the bad weather will reach the Northeast as well. On the back end of the storm, a band of snow could impact parts of the Midwest, including Chicago and Milwaukee.Copyright © 2020, ABC Audio. All rights reserved.last_img read more

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